Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort
Year: 2014
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. METHODS: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. RESULTS: We observed no association between IGF-I and EOC overall or by tumour characteristics. CONCLUSIONS: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.
Source: British Journal of Cancer
DOI: 10.1038/bjc.2014.566
Authors: J Ose, R T Fortner, H Schock, P H Peeters, N C Onland-Moret, H B Bueno-de-Mesquita, E Weiderpass, I T Gram, K Overvad, A Tjonneland, L Dossus, A Fournier, L Baglietto, A Trichopoulou, V Benetou, D Trichopoulos, H Boeing, G Masala, V Krogh, A Matiello, R Tumino, M Popovic, M Obón-Santacana, N Larrañaga, E Ardanaz, M-J Sánchez, V Menéndez, M-D Chirlaque, R C Travis, K-T Khaw, J Brändstedt, A Idahl, E Lundin, S Rinaldi, E Kuhn, I Romieu, M J Gunter, M A Merritt, E Riboli, R Kaaks
Institutions: German Cancer Research Center, University Medical Center Utrecht, National Institute for Public Health and the Environment, Imperial College London, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway, Aarhus University, Danish Cancer Society, Inserm, Centre de recherche en Epidémiologie et Santé des Populations, The University of Melbourne, Cancer Council Victoria, Academy of Athens, Hellenic Health Foundation, National and Kapodistrian University of Athens, Harvard University, German Institute of Human Nutrition, Istituto per lo Studio e la Prevenzione Oncologica, Fondazione IRCCS Istituto Nazionale dei Tumori, Federico II University Hospital, University of Naples Federico II, Piedmont Reference Center for Epidemiology and Cancer Prevention, University of Turin, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Biogipuzkoa Health Research Institute, Instituto de Salud Pública de Navarra, Centro de Investigación Biomédica en Red, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, University of Oxford, University of Cambridge, Umeå University, Centre international de recherche sur le cancer
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Funders: World Health Organization, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, National Institute for Health and Care Research, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Ligue Contre le Cancer, Stavros Niarchos Foundation, Deutsche Krebshilfe, Institut Gustave-Roussy, Hellenic Health Foundation
OpenAlex ID: W1994289510