Work

11: Therapeutic Manipulation of the Stem Cell Niche

Year: 2007

Type: article

Abstract: Altering stem cell function in normal and disease settings has implications for regenerative medicine and for the current practice of stem cell transplantation. Emphasis has generally been placed on the stem cell as a cell autonomous unit, however in vivo these cells are clearly responsive to distinct physiologic cues provided by their microenvironment. The ability of specific anatomic sites to provide regulatory input is what defines these sites as stem cell niches and offers a distinct set of targets for developing stem cell based therapeutics.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2007.08.019

Author: David Scadden

Institutions: Harvard University, Massachusetts General Hospital, Harvard Stem Cell Institute

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650