Work

4-Log ex-vivo T-Lymphocyte Depleted Myeloablative HLA-Matched Sibling Transplants; a Platform for Adoptive Immunotherapy Influenced by Conditioning Intensity

Year: 2011

Type: article

Abstract: Allogeneic hematopoietic stem cell transplantation(HSCT) must serve as a platform for adoptive cellular immunotherapy to fully exploit graft versus leukemia effects. We have developed a 4-log ex-vivo T lymphocyte depleted HSCT with minimal graft versus host disease (GvHD) prophylaxis followed by elective donor lymphocyte infusion at day 90. A lymphodepleted environment without immunosuppression would favor homeostatic expansion of adoptively infused cells in future protocols. 39 patients with hematologic malignancies underwent allogeneic HSCT with a graft from their HLA-identical siblings.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2010.12.404