Work

Drug delivery: Cellular Association and Assembly of a Multistage Delivery System Small 12/2010

Year: 2010

Type: article

Abstract: The cover image shows a pseudo-colored scanning electron microscopy image of a macrophage with two adherent discoidal porous silicon microparticles. Filopodia extends from the cell surface to initiate cellular uptake of the microparticles by phagocytosis. The oxidized silicon microparticle has a negative surface charge and a diameter of 3.2 µm. Aminosilyation of the silicon surface introduces free amines and a positive surface charge. The pore openings are approximately 50 nm in diameter and can be tuned to accommodate diverse cargo such as iron oxide nanoparticles for imaging and drug-encapsulated polymeric micelles or liposomes for therapeutic applications. The surface of the microparticle is readily functionalized with targeting ligands to direct surface adhesion and cellular uptake. For more information, please read the Full Paper “Cellular Association and Assembly of a Multistage Delivery System” by R. E. Serda, M. Ferrari, et al., beginning on page 1329.

Source: Small

DOI: 10.1002/smll.201090037

Authors: Rita E. Serda, Aaron Mack, Merlyn Pulikkathara, Ana Maria Zaske, Ciro Chiappini, Jean R. Fakhoury, Douglas Webb, Biana Godin, Jodie L. Conyers, Xue W. Liu, James A. Bankson, Mauro Ferrari

Institutions: The University of Texas Health Science Center at Houston, The University of Texas at Austin, The University of Texas MD Anderson Cancer Center, Rice University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1994532774

FWCI: 0.264

Cites:

Cited by: 2

Related to: 10