Work

AEG-1–AKT2: A novel complex controlling the aggressiveness of glioblastoma

Year: 2015

Type: article

Abstract: Expression of AEG-1 (also known as MTDH or LYRIC) is elevated in many cancers including glioblastoma multiforme (GBM), in which it functions as an oncogene. AEG-1 activates AKT signaling and physically interacts with AKT2 in GBM. Disruption of this interaction reduces glioma cell survival and invasion, uncovering a novel potential target for development of an effective therapy against GBM.

Source: Molecular & Cellular Oncology

DOI: 10.4161/23723556.2014.995008

Authors: Luni Emdad, Bin Hu, Swadesh K Das, Devanand Sarkar, Paul B Fisher

Institutions: Virginia Commonwealth University, VCU Massey Comprehensive Cancer Center

Language: English

Topic: Cancer Mechanisms and Therapy

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590