Work

Delivery of Ricin Toxin A‐Chain by Peptide‐Targeted Mesoporous Silica Nanoparticle‐Supported Lipid Bilayers

Year: 2012

Type: article

Abstract: Mesoporous silica nanoparticle-supported lipid bilayers, or "protocells", exhibit a high loading capacity, enhanced colloidal stability, and peptide-directed, cell-specific uptake, making them especially well-suited for targeted delivery of protein toxins to cancer. Protocells loaded with ricin toxin A-chain (RTA) and targeted to hepatocellular carcinoma cause complete cell death at 30 pM of RTA without affecting the viability of control hepatocytes.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201200022

Authors: Katharine Epler, David Padilla, Genevieve Phillips, Peter Crowder, Robert Castillo, Dan Wilkinson, Brian Wilkinson, Cameron Burgard, Robin Kalinich, Jason Townson, Bryce Chackerian, Cheryl Willman, David Peabody, Walker Wharton, C. Jeffrey Brinker, Carlee Ashley, Eric Carnes

Institutions: University of New Mexico, Sandia National Laboratories, UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Sandia National Laboratories California

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Eye Institute, National Cancer Institute

Awards: G1362743929, G1723691117, G935009936

OpenAlex ID: W1994546444

FWCI: 1.326

Cites: 29

Cited by: 44

Related to: 10