Work

Rethinking 5-HT 1A Receptors: Emerging Modes of Inhibitory Feedback of Relevance to Emotion-Related Behavior

Year: 2012

Type: review

Abstract: The complexities of the involvement of the serotonin transmitter system in numerous biological processes and psychiatric disorders is, to a substantial degree, attributable to the large number of serotonin receptor families and subtypes that have been identified and characterized for over four decades. Of these, the 5-HT(1A) receptor subtype, which was the first to be cloned and characterized, has received considerable attention based on its purported role in the etiology and treatment of mood and anxiety disorders. 5-HT(1A) receptors function both at presynaptic (autoreceptor) and postsynaptic (heteroreceptor) sites. Recent research has implicated distinct roles for these two populations of receptors in mediating emotion-related behavior. New concepts as to how 5-HT(1A) receptors function to control serotonergic tone throughout life were highlights of the proceedings of the 2012 Serotonin Club Meeting in Montpellier, France. Here, we review recent findings and current perspectives on functional aspects of 5-HT(1A) auto- and heteroreceptors with particular regard to their involvement in altered anxiety and mood states.

Source: ACS Chemical Neuroscience

DOI: 10.1021/cn3002174

Authors: Stefanie C. Altieri, Alvaro L. Garcia-Garcia, E. David Leonardo, Anne M. Andrews

Institutions: University of California, Los Angeles, New York State Psychiatric Institute, Columbia University, California NanoSystems Institute

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Mental Health