Work

The use of higher dose clofarabine in adults with relapsed acute lymphoblastic leukemia

Year: 2009

Type: article

Abstract: The standard dose of clofarabine is 52 mg/m2 for pediatrics and 40 mg/m2 in adults. Clofarabine dosed at 52 mg/m2 was used in adult patients with refractory ALL to maximize response before allo-HSCT. All patients had a significant response to therapy. Published pharmacokinetic analysis revealed no difference in peak plasma or intracellular concentrations at clofarabine dosed above 40 mg/m2, yet inhibition of replication in leukemia cells was only sustained over 24 hr at 55 mg/m2. Despite this, there have been no reports of high dose clofarabine used in this setting. Our experience implies that there may be a niche role for clofarabine in reducing disease burden before allo-HSCT for adults with relapsed ALL.

Source: American Journal of Hematology

DOI: 10.1002/ajh.21365

Authors: Bradley A. McGregor, Alexander W. Brown, Michael B. Osswald, Michael R. Savona

Institutions: Brooke Army Medical Center, The University of Texas at San Antonio Health Science Center

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,450