Work

Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA

Year: 2003

Type: article

Abstract: Helicobacter pylori translocates the protein CagA into gastric epithelial cells and has been linked to peptic ulcer disease and gastric carcinoma. We show that injected CagA associates with the epithelial tight-junction scaffolding protein ZO-1 and the transmembrane protein junctional adhesion molecule, causing an ectopic assembly of tight-junction components at sites of bacterial attachment, and altering the composition and function of the apical-junctional complex. Long-term CagA delivery to polarized epithelia caused a disruption of the epithelial barrier function and dysplastic alterations in epithelial cell morphology. CagA appears to target H. pylori to host cell intercellular junctions and to disrupt junction-mediated functions.

Source: Science

DOI: 10.1126/science.1081919

Authors: Manuel R. Amieva, Roger Vogelmann, Antonello Covacci, Lucy S. Tompkins, W. James Nelson, Stanley Falkow

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Helicobacter pylori-related gastroenterology studies

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green