MDR1Genetic Polymorphism Does Not Modify either Cell Permissiveness to HIV‐1 or Disease Progression before Treatment
Year: 2004
Type: article
Study design: Observational Study
Abstract: Nonphysiological overexpression of the ABC transporter P-glycoprotein (P-gp), which is encoded by MDR1, has been associated with reduced susceptibility to human immunodeficiency virus (HIV) type 1 infection in vitro. We analyzed (1) the expression and genotype of MDR1 and their relationship to HIV-1 permissiveness of CD4+ T cells from 128 healthy blood donors and (2) the role that alleles of MDR1 exons 21 and 26 play in modifying disease progression in 411 HIV-1-infected individuals. Differences in physiological levels of MDR1 expression did not modify HIV-1 infection in vitro, nor did MDR1 alleles and haplotypes significantly influence either permissiveness to infection in vitro or disease progression in vivo before the initiation of treatment.
DOI: 10.1086/380134
Authors: Gabriela Bleiber, Margaret May, Carlos Suarez, Raquel Martinez, Catia Marzolini, Matthias Egger, Amalio Telenti, the Swiss HIV Cohort Study
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1995006058