Excision Repair in Mammalian Cells
Year: 1995
Type: review
Abstract: There are two types of structural anomalies that lead to mutation, a permanent change in DNA sequence. The first class involves normal bases in abnormal sequence context (mismatch, bulge, loop). The second class, which is referred to as DNA damage or DNA lesion, involves abnormal nucleotides (modified, fragmented, cross-linked) in normal sequence context. DNA lesions, in addition to causing mutations, also constitute replication and transcription blocks.
Source: Journal of Biological Chemistry
Author: Aziz Sancar
Institution: University of North Carolina at Chapel Hill
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W1995021789