Work

Comparison of Disk Diffusion and Etest Methods to Determine the Susceptibility ofStaphylococcus aureusCirculating in Riyadh, Saudi Arabia to Fusidic Acid

Year: 2012

Type: article

Abstract: Fusidic acid is a common therapy for staphylococcal infections in Saudi Arabia, but reports have suggested high rates of resistance among clinical isolates. Susceptibility testing of S. aureus to fusidic acid is further complicated by the lack of consensus on mean inhibitory concentrations (MIC) and disk diffusion cutoffs to determine resistance. The purpose of this study was to determine the correlation between disk diffusion and Etest determined MIC susceptibility results in clinical isolates of S. aureus from a large academic hospital in Riyadh, Saudi Arabia. Our data demonstrate excellent correlation between Etest determined MIC and disk diffusion susceptibility data, using either previously proposed zone sizes of ≥21 mm as susceptible and ≤18 mm as resistant or the EUCAST recommended zone size of ≤24 mm for resistance, in an area with relatively high rates of fusidic acid resistance.

Source: International Journal of Microbiology

DOI: 10.1155/2012/391251

Authors: Ali M. Somily, David R. Peaper, Elijah Paintsil, Thomas S. Murray

Institutions: King Saud University, King Khalid University Hospital, Yale University, VA Connecticut Healthcare System, Quinnipiac University

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000