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Keeping a good rep in meiosis: Mind the CDK

Year: 2009

Type: editorial

Abstract: Among the key processes that cyclin-dependent kinase (CDK) activities regulate during the mitotic cell cycle are initiation of DNA replication, leading to complete duplication of the genetic material, and prevention of additional rounds of DNA replication prior to cell division. In the absence of proper DNA replication control, aneuploidy can arise with serious negative consequences to cell health. Regulation of DNA replication is also critical for those cells that undergo meiosis, the specialized form of cell division that leads to generation of haploid gametes from diploid precursors. As in the cell cycle, CDK directs DNA replication during meiotic progression. However, there is an added level of complexity in meiosis due to events involved in halving the chromosome content.

Source: Cell Cycle

DOI: 10.4161/cc.8.9.8283

Authors: George Brush, Nicole A. Najor

Institutions: Wayne State University, The Barbara Ann Karmanos Cancer Institute

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: National Cancer Institute

Awards: Enhancing neoadjuvant chemotherpay responses with targeted T cells, CANCER CENTER SUPPORT GRANT

OpenAlex ID: W1995114258

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Cited by: 2

Related to: 10