Work

Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin

Year: 1988

Type: article

Abstract: The proliferating cell nuclear antigen (PCNA or cyclin) is a nuclear protein recently identified as a cofactor of DNA polymerase delta. When exponentially growing Balb/c3T3 cells are exposed to antisense oligodeoxynucleotides to PCNA, both DNA synthesis and mitosis are completely suppressed. A corresponding sense oligodeoxynucleotide has no inhibitory effects. These experiments indicate that PCNA (cyclin) is important in cellular DNA synthesis and in cell cycle progression.

Source: Science

DOI: 10.1126/science.2897717

Authors: Dariusz Jaskulski, J. Kim deRiel, W. Edward Mercer, Bruno Calabretta, Renato Baserga

Institution: Temple University

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute