Work

Sequence‐Specific Crosslinking of Electrospun, Elastin‐Like Protein Preserves Bioactivity and Native‐Like Mechanics

Year: 2012

Type: article

Abstract: A nanoscale mimic of the extracellular matrix is electrospun from a highly tunable family of elastin-like proteins. A sequence-specific, two-step crosslinking procedure is developed to preserve the nanofiber morphology, elastin-like mechanics, and specific bioactivity. Rodent marrow stromal cells show sequence-specific adhesion on the matrices, which are imaged using label-free coherent anti-Stokes Raman scattering (CARS) microscopy.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201200115

Authors: Patrick L. Benitez, Jeffrey A. Sweet, Helen Fink, Krishna P. Chennazhi, Shantikumar V. Nair, Annika Enejder, Sarah C. Heilshorn

Institutions: Stanford University, Chalmers University of Technology, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: 3D Bioengineering Strategies to Mimic Human Skeletal Muscle Progenitor Cell Niche, G4915691071, NANO-PATTERNING OF BIOMATERIALS FOR BLOOD-VESSEL FORMATION IN ARTIFICIAL TISSUES, Engineering 3D in vitro niches to reveal fundamentals of cellular biomechanics, G7267873024

OpenAlex ID: W1995260790

FWCI: 2.164

Cites: 37

Cited by: 45

Related to: 10