Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage
Year: 2010
Type: article
Abstract: Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro. This study was designed to test the hypothesis that hydrogen-rich PBS may be an effective radioprotective agent in vitro. Compared to cells pretreated without hydrogen, we demonstrated that treating cells with hydrogen-rich PBS before irradiation could significantly inhibit IR-induced apoptosis, increase viability of human intestinal crypt cells, significantly increase endogenous antioxidant, and decrease malondialdehyde and 8-hydroxydeoxyguanosine concentrations of human lymphocyte AHH-1 cells. It is concluded that hydrogen has a potential as an effective and safe radioprotective agent.
DOI: 10.2298/ntrp1001023q
Authors: Liren Qian, Bailong Li, Fei Cao, Yuecheng Huang, Shulin Liu, Jianming Cai, Fu Gao
Institution: Second Military Medical University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $161
OpenAlex ID: W1995309420