Work

Epigenetics of Autoantigens: New Opportunities for Therapy of Autoimmune Diseases

Year: 2013

Type: review

Abstract: The field of epigenetics requires that traditional divisions between scientific disciplines give way to cross-fertilization of concepts and ideas from different areas of investigation. Such is the case with research in autoimmunity. Recent discoveries of stimuli that induce autoimmunity reveal that epigenetic marks of autoantigens are recognized by autoreactive B and T cell receptors. Thus, insights into the initiation of autoimmunity, its prevention and therapy will arise from understanding the biochemistry, cell biology and microbiology of autoantigen epigenetics. Here, we highlight potential benefits from the inhibition of a histone modifying enzyme and the administration of a phosphorylated, spliceosome-derived peptide, in the treatment of autoimmunity.

Source: Genetics & Epigenetics

DOI: 10.4137/geg.s12144

Authors: Marko Radic, Sylviane Muller

Institutions: University of Tennessee Health Science Center, Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500