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Pattern of SIVagm Infection in Patas Monkeys Suggests that Host Adaptation to Simian Immunodeficiency Virus Infection May Result in Resistance to Infection and Virus Extinction

Year: 2010
Type: article
Abstract: Patas monkeys were not reported to carry species‐specific simian immunodeficiency virus (SIV), but cross‐species transmission of SIVagm to patas monkeys occurred in the wild. We report that patas monkeys share immunophenotypic features with natural hosts of SIV; that is, low levels of CD4+ T cells and low CCR5 expression on CD4+ T cells. In 1 patas monkey with undetectable levels of CD4+ T cells, experimental exposure to SIVagm did not result in infection. The other experimentally infected patas monkeys showed an infection pattern similar to SIV infection in natural hosts. Thus, down‐regulation of CD4 and CCR5 expression on CD4+ T cells may effectively control human immunodeficiency virus acquisition and result in SIV extinction.
DOI: 10.1086/655970
Authors: Cristian Apetrei, Thaidra Gaufin, Rajeev Gautam, Carol Vinton, Vanessa Hirsch, Mark Lewis, Jason Brenchley, Ivona Pandrea
Language: English
Subfield: Virology
Open Access status: green
Awards: G1454932863, G2011619016, G273869597, G2994435436, G3068004703, G401230023, G434789455, G4961442110, G5361389929, MOUSE MODELS OF CANCER, BONE DISEASE, AND LACTATION, Pathogenesis of SIV in African green monkeys, G9000009590, G9000027727, G9000106381
OpenAlex ID: W1995358925
FWCI: 0.948
Cites: 12
Cited by: 32
Related to: 10