Work

Abrogation of Brd4 cellular function contributes to the oncogenic mechanisms of translocation t(15;19)-associated carcinoma

Year: 2013

Type: article

Abstract: Background Brd4 (bromodomain-containing protein 4) is an important epigenetic reader that plays a crucial role in cellular proliferation and cell cycle progression. Several recent studies have identified Brd4 as a critical therapeutic target in a number of different cancers. Brd4 is also an important target of several oncogenic viruses and the translocation t (15;19) that accounts for a highly aggressive carcinoma. The t(15;19) translocation results in the novel in-frame fusion of the Brd4 N-terminal component with almost the entire sequence of Nut (Nuclear protein in testis) molecule, leading to the formation of a novel fusion oncogene, Brd4-Nut. The mechanism by which the Brd4-Nut fusion product contributes to oncogenesis remains to be clearly defined.

Source: Epigenetics & Chromatin

DOI: 10.1186/1756-8935-6-s1-p101

Authors: Ranran Wang, Christine M Heifer, Jianxin You

Institution: University of Pennsylvania

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190