Work

Synthesis of 8-Heteroaryl-2′-deoxyguanosine Derivatives

Year: 2008

Type: article

Abstract: We describe the synthesis of 8-heteroaromatic-2'-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2'-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin derivatives of 2-pyridylbromides either with or without microwave irradiation in good yields.

Source: Synlett

DOI: 10.1055/s-2007-1077795

Authors: José Rivera, Gerard Hobley, Vladimir Gubala, María Del C. Rivera-Sánchez

Institutions: University of Puerto Rico at Río Piedras, Dublin City University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green