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Evidence for icaADBC -Independent Biofilm Development Mechanism in Methicillin-Resistant Staphylococcus aureus Clinical Isolates

Year: 2005

Type: article

Abstract: Synthesis of a polysaccharide adhesin by icaADBC-encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant Staphylococcus aureus isolates, environmental activation of icaADBC did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was icaADBC independent. Apparently, an environmentally regulated, ica-independent mechanism(s) of biofilm development exists in S. aureus clinical isolates.

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.43.4.1973-1976.2005

Authors: Fidelma Fitzpatrick, Hilary Humphreys, James P. O'Gara

Institutions: Royal College of Surgeons in Ireland, Beaumont Hospital

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: University of Nebraska Medical Center