Work

Calculating the Bending Modulus for Multicomponent Lipid Membranes in Different Thermodynamic Phases

Year: 2013

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide We establish a computational approach to extract the bending modulus, K C, for lipid membranes from relatively small-scale molecular simulations. Fluctuations in the splay of individual pairs of lipids faithfully inform on K C in multicomponent membranes over a large range of rigidities in different thermodynamic phases. Predictions are validated by experiments even where the standard spectral analysis-based methods fail. The local nature of this method potentially allows its extension to calculations of K C in protein-laden membranes.

Source: Journal of Chemical Theory and Computation

DOI: 10.1021/ct400492e

Authors: George Khelashvili, Benjamin Kollmitzer, Peter Heftberger, Georg Pabst, Daniel Harries

Institutions: Weill Cornell Medicine, University of Graz, Hebrew University of Jerusalem

Language: English

Topic: Lipid Membrane Structure and Behavior

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $2,123

Funders: Minerva Foundation, Austrian Science Fund