Fluorescent Sensors for Measuring Metal Ions in Living Systems
Year: 2014
Type: review
Abstract: a Fluorescence Signal 4566 2.3.Classes of Sensors for Live-Cell Imaging 4568 2.3.1.Molecular Probes 4568 2.3.2.Genetically Encoded Probes 4568 2.3.3.Hybrid Probes 4569 3. Important Considerations for Introduction of Sensors 4569 3.1.Factors Affecting the Intracellular Concentration of Sensors 4569 3.2.Buffering 4570 3.3.Localization 4570 3.3.1.Factors Governing Localization of Molecular Probes 4571 3.3.2.Genetic Targeting of Probes 4572 4. A Brief History of Visualizing Cellular Metal Ion Distribution with Probes 4572 5. Probes for Zinc 4576 5.1.Zinc Homeostasis 4576 5.2.Small-Molecule Probes for Zn 2+ 4576 5.2.1.Intensity-Based Probes 4576 5.2.2.Ratiometric Probes for Zn 2+ 4580 5.3.Genetically Encoded Sensors for Zn 2+ 4581 5.4.Hybrid Probes for Zn 2+ 4583 6.Probes for Copper 4584 7. Probes for Iron 4587 7.1.Iron Homeostasis 4587 7.2.Early Probes for Labile Iron 4588 7.3.Probes for Fe 2+ 4588 7.4.Probes for Fe 3+ 4589 8. Available Fluorescent Probes for Other Biological Metals 4591 8.1.Manganese (Mn 2+ ) 4591 8.2.Nickel (Ni 2+ ) 4592 8.3.Cobalt (Co 2+ ) 4592 9. Probes for Toxic Metals 4592 9.1.Lead (Pb 2+ ) 4592 9.2.Cadmium (Cd 2+ ) 4594 9.3.Mercury (Hg 2+ ) 4594 10.
Source: Chemical Reviews
DOI: 10.1021/cr400546e
Institutions: University of Colorado Boulder, University of Colorado System
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W1995713813