Work

Directing Dendritic Cell Immunotherapy Towards Successful Cancer Treatment

Year: 2009

Type: article

Abstract: The use of dendritic cells (DCs) for tumor immunotherapy represents a powerful approach for harnessing the patient's own immune system to eliminate tumor cells. However, suboptimal conditions for generating potent immunostimulatory DCs, as well as the induction of tolerance and suppression mediated by the tumors and its microenvironment have contributed to limited success. Combining DC vaccines with new approaches that enhance immunogenicity and overcome the regulatory mechanisms underlying peripheral tolerance may be the key to achieving effective and durable anti-tumor immune responses that translate to better clinical outcomes.

Source: Immunotherapy

DOI: 10.2217/imt.09.43

Authors: Rachel Lubong Sabado, Nina Bhardwaj

Institutions: NYU Langone Health, New York University

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Doris Duke Charitable Foundation, Bill and Melinda Gates Foundation, Emerald Foundation, National Institute of Allergy and Infectious Diseases