Work

Design and assembly of supramolecular dual-modality nanoprobes

Year: 2015

Type: article

Abstract: We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods. These molecular probes can spontaneously associate into spherical nanoparticles under physiological conditions. We demonstrate the use of these supramolecular nanoprobes for live-cell optical imaging, as well as their potential use as MRI contrast agents after complexation with gadolinium. Our results suggest that self-assembly into supramolecular nanoprobes presents an effective means to enhance and tune the relaxivities of molecular probes.

Source: Nanoscale

DOI: 10.1039/c5nr01518a

Authors: Shuang Liu, Pengcheng Zhang, Sangeeta Ray Banerjee, Jiadi Xu, Martin G. Pomper, Honggang Cui

Institutions: Johns Hopkins University, Kennedy Krieger Institute, Sidney Kimmel Cancer Center, Sidney Kimmel Comprehensive Cancer Center

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green