Correlation of changes in α2‐adrenoceptor number and locomotor responses to clonidine following clorgyline discontinuation
Year: 1983
Type: article
Abstract: [3H]-clonidine binding in vitro and the locomotor response to clonidine in vivo were studied over an eight week period following four weeks of treatment with the monoamine oxidase-inhibiting antidepressant, clorgyline (1 mg kg-1 day-1). Long-term clorgyline administration caused decreases in responsiveness to clonidine and in the number of alpha 2-adrenoceptors; these changes reverted towards pretreatment values very gradually over an eight week period following discontinuation of the drug. This study provides some of the first detailed evidence regarding the slow return of adaptional changes following discontinuation of an antidepressant drug in animals and has implications for understanding some delayed drug interactions associated with MAO-inhibiting antidepressants in man.
Source: British Journal of Pharmacology
Authors: C.S. Aulakh, R.M. Cohen, C. McLellan, D.L. Murphy
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1995920164