Work

Iron(II) Bromide-Catalyzed Intramolecular C–H Bond Amination [1,2]-Shift Tandem Reactions of Aryl Azides

Year: 2012

Type: article

Abstract: Iron(II) bromide catalyzes the transformation of ortho-substituted aryl azides into 2,3-disubstituted indoles through a tandem ethereal C-H bond amination [1,2]-shift reaction. The preference for the 1,2-shift component of the tandem reaction was established to be Me < 1° < 2° < Ph.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja3113565

Authors: Quyen Nguyen, Tuyen Nguyen, Tom G. Driver

Institution: University of Illinois Chicago

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, University of Illinois at Urbana-Champaign, National Institute of General Medical Sciences

Award: N-Heterocycles from Azides through Rhodium-Catalyzed Nitrenoid Transfer