Work

Recombination mediates production of an extrachromosomal circular DNA containing a transposon-like human element, THE-1

Year: 1989

Type: article

Abstract: An abundant class of HeLa extrachromosomal circular DNA containing the transposon-like element, THE-1, is shown to arise via site specific recombination. The chromosomal locus from which these circles are derived, however, is single-copy. Northern blot analysis detects homology to two polyadenylated RNAs in HeLa cells. The possible presence of an origin of replication and its role in generating these small polydisperse circles is discussed.

Source: Nucleic Acids Research

DOI: 10.1093/nar/17.20.8327

Authors: Ravi Misra, A. Gregory Matera, Carl W. Schmid, Mark G. Rush

Institutions: NYU Langone Health, New York University, University of California, Davis

Language: English

Topic: Chromosomal and Genetic Variations

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, U.S. Public Health Service, National Institute of General Medical Sciences