Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta‐analysis of nine studies in the CHARGE consortium
Year: 2015
Type: article
Abstract: SCOPE: Tissue concentrations of omega-3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega-3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha-linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid. METHODS AND RESULTS: We conducted meta-analyses (N = 11 668) evaluating interactions between dietary fatty acids and genetic variants (rs174538 and rs174548 in FADS1 (fatty acid desaturase 1), rs7435 in AGPAT3 (1-acyl-sn-glycerol-3-phosphate), rs4985167 in PDXDC1 (pyridoxal-dependent decarboxylase domain-containing 1), rs780094 in GCKR (glucokinase regulatory protein), and rs3734398 in ELOVL2 (fatty acid elongase 2)). Stratification by measurement compartment (plasma versus erthyrocyte) revealed compartment-specific interactions between FADS1 rs174538 and rs174548 and dietary alpha-linolenic acid and linoleic acid for docosahexaenoic acid and docosapentaenoic acid. CONCLUSION: Our findings reinforce earlier reports that genetically based differences in circulating fatty acids may be partially due to differences in the conversion of fatty acid precursors. Further, fatty acids measurement compartment may modify gene-diet relationships, and considering compartment may improve the detection of gene-fatty acids interactions for circulating fatty acid outcomes.
Authors: Caren E. Smith, Jack L. Follis, Jennifer A. Nettleton, Millennia Foy, Jason H.Y. Wu, Yiyi Ma, Toshiko Tanaka, Ani W. Manichakul, Hongyu Wu, Audrey Y. Chu, Lyn M. Steffen, Myriam Fornage, Dariush Mozaffarian, Edmond K. Kabagambe, Luigi Ferruci, Yii‐Der Ida Chen, Stephen S. Rich, Luc Djoussé, Paul M. Ridker, Weihong Tang, Barbara McKnight, Michael Y. Tsai, Stefania Bandinelli, Jerome I. Rotter, Frank B. Hu, Daniel I. Chasman, Bruce M. Psaty, Donna K. Arnett, Irena B. King, Qi Sun, Lu Wang, Thomas Lumley, Stephanie E. Chiuve, David S. Siscovick, José M. Ordovás, Rozenn N. Lemaitre
Institutions: Tufts University, Jean Mayer Human Nutrition Research Center on Aging, University of St. Thomas - Texas, The University of Texas Health Science Center at Houston, The University of Sydney, The George Institute for Global Health, National Institute on Aging, University of Virginia, Harvard University, Brigham and Women's Hospital, University of Minnesota, Vanderbilt University, The Lundquist Institute, Harbor–UCLA Medical Center, VA Boston Healthcare System, University of Washington, Azienda Sanitaria di Firenze, Group Health Cooperative, Kaiser Permanente Washington Health Research Institute, University of Alabama at Birmingham, University of New Mexico, University of Auckland, Spanish National Centre for Cardiovascular Research
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: G1052397333, G1056654229, G1135917780, G1141534940, G1220223050, G1243299691, Dietary Patterns and Risk of Cardiovascular Disease, G1261793039, MESA, CORONARY HEART DISEASE AND STROKE, G1271251741, G1276754516, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1327305488, G1332411685, G1345547317, G1409423729, G1462415530, G1527150935, G15705064, G1595007403, CORONARY HEART DISEASE AND STROKE, G1640378483, G1691174148, G173303992, G1774001260, G1910112017, G1941623656, G202194050, G2111759553, G2144938473, G2193588257, G2194386449, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G22458031, G229684361, G2391884931, MESA, G247538147, Institute for Clinical and Translational Research (UL1), Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), G2555954497, G261675466, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G2716548166, G2796414281, G2818629771, G2818913090, MESA, G2837638605, G290884426, G291913881, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G297113894, G3041236093, G3045517347, WGA Study to Identify Genetic Variants Associated with CV Events in CHS, G3059241284, G3114902838, G316474162, G3211455882, G3220743633, UCLA Clinical and Translational Science Institute, G3342643523, G3410686264, G3426488059, G3462919067, Dietary Etiologies of Heart Disease, G3647016462, Genetic and Environmental Determinants of Triglycerides, G3696925611, GWA for Gene-Environment Interaction Effects Influencing CHD, MESA, G3950177779, Dietary and Hormonal Determinants of Cancer in Women, G3984593164, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, G405311360, G4299786064, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), G4429312988, Role of fatty acid metabolism for the prevention of sudden cardiac death, G4562300860, G457330776, Genome Wide Association Coordinating Center, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA, G5086681883, GWAS of longitudinal blood pressure profiles from young adulthood to middle-age, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, G536099884, Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood, G5479317095, Epidemiology of Venous Thrombosis and Pulmonary Embolism, G558986044, G567847597, G573134505, G581887176, The Women's Health Study: Addition of New Data to Maximize its Research Impact, CHS Events Follow-up Study, G6008908520, G6038209881, G6226795708, MESA, G6548750934, G66341962, CHS-Transition Phase, SNP HEALTH ASSOCIATION RESOURCE (SHARE), Genomewide Association Study of Lipid Response to Fenofibrate and Dietary Fat, TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN, G690901646, G7176672723, Prospective Studies of Diet and Cancer in Men and Women, MESA, G777822606, CHS Events Follow-up Study, G78770644, Women's Health Study: Continued Follow-up, Cancer Epidemiology Cohort in Male Health Professionals, G814381192, Vitamin D Status, Vitamin D Receptor Gene Variants, and Hypertension Risk, G8624473664, Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis, HISPANIC SECONDARY STROKE PREVENTION INITIATIVE, G878552033, G885693336, Diabetes Research Center (DRC), From GWAS loci to blood pressure genes, variants & mechanisms - Renewal, RISK FACTORS FOR CVD IN WOMEN, G931818222, G991334795
OpenAlex ID: W1996071127