Work

Resistance-Mediating Plasmodium falciparum pfcrt and pfmdr1 Alleles after Treatment with Artesunate-Amodiaquine in Uganda

Year: 2007

Type: article

Abstract: Key parasite polymorphisms were assessed in subjects treated for malaria with artesunate-amodiaquine in Tororo, Uganda. For pfcrt, all of the isolates tested had the CVIET haplotype. For pfmdr1, 86Y and 1246Y were common at baseline and their prevalences were significantly higher in new isolates after therapy, indicating that treatment selected for mutations associated with a decreased response to amodiaquine.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00012-07

Authors: Samuel L. Nsobya, Christian Dokomajilar, Moses Joloba, Grant Dorsey, Philip J. Rosenthal

Institutions: Makerere University, University of California, San Francisco

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Fogarty International Center