Work

Additional antibiotic use and preterm birth among bacteriuric and nonbacteriuric pregnant women

Year: 2008

Type: article

Abstract: OBJECTIVE: To determine the risk of preterm birth related to use of additional antibiotics. METHODS: Women with Group B streptococcal (GBS) bacteriuria and women with negative urine cultures in a hospital-wide research registry were included. The impact of prenatal antibiotics in addition to those used to treat GBS bacteriuria was assessed. Logistic regression was used to determine the risk of preterm birth among bacteriuric women who received "other antibiotics". RESULTS: A total of 203 women with GBS bacteriuria and 220 women with negative cultures were included. The frequency of preterm birth was 16% (35/220) for women in the control group, 16% (19/120) for women with bacteriuria not receiving additional antibiotics, and 28% (23/83) for women with bacteriuria who received antibiotics for "other indications". Among women with GBS bacteriuria, the risk of preterm birth was increased with the use of "other antibiotics" (adjusted odds ratio, 2.7; 95% confidence interval, 1.2-6.1). CONCLUSION: Among women with GBS bacteriuria, exposure to additional antibiotics is associated with an increased risk of preterm birth.

Source: International Journal of Gynecology & Obstetrics

DOI: 10.1016/j.ijgo.2008.04.005

Authors: Brenna L. Anderson, Hyagriv N. Simhan, Kathryn Simons, Harold C. Wiesenfeld

Institutions: Brown University, University of Pittsburgh

Language: English

Topic: Neonatal and Maternal Infections

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Eunice Kennedy Shriver National Institute of Child Health and Human Development