Reduced Intensity Conditioning (RIC) Allogeneic Stem Cell Transplantation (AlloSCT) In Children and Adolescent Recipients is Associated With Very Low Regimen Related and Non-Relapse Mortality (NRM): However, Chemonaive Patients Following Umbilical Cord Blood Transplant (UCBT) have a Higher Incidence of Primary Graft Failure (PGF)
Year: 2009
Type: article
Abstract: Myeloablative-AlloSCT is associated with a 20–40% NRM in the first 100 days post AlloSCT. RIC may decrease this high mortality but data in pediatric recipients is limited (Satwani/Cairo et al, BBMT 2005; PBC 2007). We evaluated the feasibility and toxicity of RI-AlloSCT in 83 children and adolescents with malignant (n = 47) and non-malignant (n = 36) disease: Median age 10 ± 6.7yrs, UCB (n = 42), matched family donor (MFD) (n = 32), matched unrelated donor (MUD) (n = 9); average risk (n = 72), poor risk (n = 11).
Authors: P. Satwani, B. Tallamy, Z. Jin, V. Kohl, J. Garvin, M. Bhatia, D. George, B. Bradley, C. van de Ven, L. Reichman, E. Morris, N. Fearon, L. Harrison, T. Shonfeld, L.A. Baxter-Lowe, J. Schwartz, R. Hawks, S. Foley, M.S. Cairo
Institutions: Columbia University, University of California, San Francisco
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W1996177330