Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex
Year: 2015
Type: review
Abstract: Phylogenetic analysis of 11 genetic loci and results from many genotyping studies revealed significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus neoformans species complex. Genealogical concordance, coalescence-based, and species tree approaches supported the presence of distinct and concordant lineages within the complex. Consequently, we propose to recognize the current C. neoformans var. grubii and C. neoformans var. neoformans as separate species, and five species within C. gattii. The type strain of C. neoformans CBS132 represents a serotype AD hybrid and is replaced. The newly delimited species differ in aspects of pathogenicity, prevalence for patient groups, as well as biochemical and physiological aspects, such as susceptibility to antifungals. MALDI-TOF mass spectrometry readily distinguishes the newly recognized species.
Source: Fungal Genetics and Biology
Institutions: Westerdijk Fungal Biodiversity Institute, Canisius-Wilhelmina Ziekenhuis, University of Phayao, Hebrew University of Jerusalem, Hadassah Medical Center, Agricultural Research Organization, Ministry of Agriculture and Rural Development, Ministry of Public Health, Department of Medical Sciences, Field Museum of Natural History, Second Military Medical University, Chinese Academy of Sciences, Shanghai Changzheng Hospital, Institute of Microbiology
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,210
Funder: Naresuan University
OpenAlex ID: W1996229802