Year: 2015
Type: article
Abstract: Integrating high contrast bubbles from ultrasound imaging with plasmonic absorbers from photoacoustic imaging is investigated. Nanoemulsion beads coated with gold nanopsheres (NEB-GNS) are excited with simultaneous light (transient heat at the GNS's) and ultrasound (rarefactional pressure) resulting in a phase transition achievable under different scenarios, enhancing laser-induced acoustic signals and enabling specific detection of nanoprobes at lower concentration. An automated platform allowed dual parameter scans of both pressure and laser fluence while recording broadband acoustic signals. Two types of NEB-GNS and individual GNS were investigated and showed the great potential of this technique to enhance photoacoustic/acoustic signals. The NEB-GNS size distribution influences vaporization thresholds which can be reached at both permissible ultrasound and light exposures at deep penetration and at low concentrations of targets. This technique, called sono-photoacoustics, has great potential for targeted molecular imaging and therapy using compact nanoprobes with potentially high-penetrability into tissue.
Source: Photoacoustics
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,200
Funders: National Science Foundation, University of Washington, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, Division of Chemical, Bioengineering, Environmental, and Transport Systems
Awards: Non-invasive trapping and imaging of circulating tumor cells in the peripheral va, Nano-agent for photoacoustic theranostics of dialysis graft/fistula occlusions, Self-Assembly of Plasmonic Nanoclusters Mediated by Localized Steric Repulsion, q4DE: A Biomarker for Image-Guided, Post-MI Hydrogel Therapy, Sensitive tumor detection with magnetomotive imaging, G8410886375, G9000181779
OpenAlex ID: W1996234224