Work

Therapeutic efficacy of combined blockade of CTLA-4 +/- PD-L1 +/- IDO is associated with re-activation of T cells directly within the tumor microenvironment

Year: 2013

Type: article

Abstract: Meeting abstracts A major subset of human cancers is associated with CD8+ T cell infiltration yet tumor rejection fails due to the dominant effects of multiple immune inhibitory mechanisms. These include expression of the inhibitory receptors CTLA-4 and PD-1 by T cells and expression of the

Source: Journal for ImmunoTherapy of Cancer

DOI: 10.1186/2051-1426-1-s1-o8

Authors: Stefani Spranger, Thomas Gajewski

Institution: University of Chicago

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,490