Work

DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos

Year: 2014

Type: preprint

Abstract: Methylation of DNA is an essential epigenetic control mechanism in mammals. During embryonic development, cells are directed toward their future lineages, and DNA methylation poses a fundamental epigenetic barrier that guides and restricts differentiation and prevents regression into an undifferentiated state. DNA methylation also plays an important role in sex chromosome dosage compensation, the repression of retrotransposons that threaten genome integrity, the maintenance of genome stability, and the coordinated expression of imprinted genes. However, DNA methylation marks must be globally removed to allow for sexual reproduction and the adoption of the specialized, hypomethylated epigenome of the primordial germ cell and the preimplantation embryo. Recent technological advances in genome-wide DNA methylation analysis and the functional description of novel enzymatic DNA demethylation pathways have provided significant insights into the molecular processes that prepare the mammalian embryo for normal development.

Source: Genes & Development

DOI: 10.1101/gad.234294.113

Authors: Daniel M. Messerschmidt, Barbara B. Knowles, Davor Solter

Institutions: Agency for Science, Technology and Research, Institute of Molecular and Cell Biology, Jackson Laboratory, Institute of Medical Biology

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

OpenAlex ID: W1996431759

Cites: 172

Cited by: 730

Related to: 10