Work

Glucocorticoids and prostate cancer treatment: friend or foe?

Year: 2014

Type: review

Abstract: Glucocorticoids have been used in the treatment of prostate cancer to slow disease progression, improve pain control and offset side effects of chemo- and hormonal therapy. However, they may also have the potential to drive prostate cancer growth via mutated androgen receptors or glucocorticoid receptors (GRs). In this review we examine historical and contemporary use of glucocorticoids in the treatment of prostate cancer, review potential mechanisms by which they may inhibit or drive prostate cancer growth, and describe potential means of defining their contribution to the biology of prostate cancer.

Source: Asian Journal of Andrology

DOI: 10.4103/1008-682x.125392

Authors: Bruce Montgomery, HeatherH Cheng, James Drechsler, ElaheA Mostaghel

Institutions: University of Washington, Seattle Cancer Care Alliance, Fred Hutch Cancer Center

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $711