Functional plasticity and robustness are essential characteristics of biological systems: Lessons learned from KLRG1‐deficient mice
Year: 2010
Type: article
Abstract: Killer cell lectin-like receptor G1 (KLRG1) receptor is considered to be a marker of terminally differentiated NK and T cells and is strongly induced by viral and other infections. KLRG1 is a C-type lectin-like inhibitory receptor, which interacts with members of the cadherin family of molecules leading to the inhibition of T- and NK-cell function. A study in this issue of the European Journal of Immunology addresses the role of KLRG1 in the maturation and differentiation of NK and T cells in vivo. Using KLRG1-deficient mice generated by homologous recombination, the study reveals that KLRG1 is dispensable for NK- and CD8+ T-cell differentiation and function in vivo. This interesting finding is discussed in this Commentary in light of the plasticity and robustness of immune response mechanisms.
Source: European Journal of Immunology
Author: Stipan Jonjic
Institution: University of Rijeka
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Funder: Unity through Knowledge Fund
OpenAlex ID: W1996526800