Year: 2013
Type: article
Study design: Case Report
Abstract: A 44-year-old woman presented with myalgia and fever.Initial laboratory results were: White blood cell (WBC) count, 7.8×10 9 /L; hemoglobin, 11.3 g/dL; platelet count, 42×10 9 /L; and lactate dehydrogenase, 619 IU/L.Peripheral blood cell morphology showed leukoerythroblastic features (nRBC, 8/100 WBCs).Abdominal computed tomography (CT) indicated hepatosplenomegaly.Bone marrow biopsy showed focal large cell aggregates with prominent nucleoli in capillaries (A, H&E stain, ×400; B, CD20 stain, ×400).These cells were positive for CD5 and CD20 and negative for CD10, CD56, CD117, CD34, TDT, and CD3.Chromosomal study showed a complex karyotype (C, 48,-X,add(X) ( p 1 1 .2 ) ,a d d ( 1 ) ( p 1 2 ) , a dd ( 2 ) ( p 1 1 .2 ) ,a d d ( 3 ) ( q 2 7 ) , d e l ( 6 ) ( q 2 1 ) -7 , a dd ( 8 ) ( p 2 1 ) , -1 3 , d e l ( 1 5 ) ( q 1 1 .2 q 1 5 ) , del(20)(q13.3),+mar1,+mar2,+mar3,+mar4,+mar5[cp3]/46,XX[17]).She was diagnosed with intravascular large B-cell lymphoma and treated with rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone (R-CHOP) combination chemotherapy.Three months after auto-peripheral blood stem cell transplantation, she was readmitted due to coughing, sputum, and myalgia.Bone marrow analysis showed an intravascular large B-cell lymphoma recurrence with normal karyotype (D, Wright-Giemsa stain, ×1,000).In a BCL6 dual-color, break-apart probe (Vysis/Abbott Molecular, Des Plaines, IL, USA) initial diagnostic specimen FISH study, 9.8% (49/500) of the cells had a 2-green 1-fusion abnormal signal pattern, suggesting 3q27 rearrangement, while no abnormal signal patterns were observed, although abnormal lymphoid cells comprised 6.8% of the bone marrow at relapse.
Source: Blood Research
Authors: Kyoung Il Jo, Rojin Park, Jong Ho Won
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,290
Funder: Soonchunhyang University
OpenAlex ID: W1996528899