On the primary site of control in the spontaneous development of small‐intestinal sucrase‐isomaltase after birth
Year: 1986
Type: article
Abstract: We have compared the appearance in the small intestine of baby rabbits, of sucrase and isomaltase activities and of the sucrase-isomaltase mRNA. For the latter we used a cDNA probe encompassing approximately 4.1 kb from the 5'-end of pro-sucrase-isomaltase cDNA [(1986) Cell 46, 227-234]. Sucrase-isomaltase mRNA and the enzyme activities developed simultaneously from the 15th day after birth onwards. Over two orders of magnitude the enzymatic activities and sucrase-isomaltase mRNA matched one another closely, thus ruling out translation as the main site of biosynthetic control during spontaneous development, while rendering very probable transcription as the primary site of control. However, we cannot rule out the possibility that, prior to day 15, sucrase-isomaltase mRNA might be degraded so rapidly that it is not translated.
Source: FEBS Letters
Institutions: University of Naples Federico II, ETH Zurich
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1996533617