Work

Asymmetric Total Synthesis and Absolute Stereochemistry of the Neuroactive Marine Macrolide Palmyrolide A

Year: 2012

Type: article

Abstract: The first asymmetric total synthesis and determination of the absolute configuration for the neuroactive marine macrolide palmyrolide A is described. The highlight of the synthesis is macrocyclization via trans-enamide formation catalyzed by copper(I) iodide and cesium carbonate. Comparison with the authentic spectral data confirms the synthesis of (+)-ent-palmyrolide A.

Source: Organic Letters

DOI: 10.1021/ol300673m

Authors: Rodolfo Tello-Aburto, Emily M. Johnson, Cheyenne K. Valdez, William A. Maio

Institution: New Mexico State University

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, New Mexico State University, National Institute of General Medical Sciences

Awards: NMSU RISE to the Postdoctorate Program YRS 18-22, G6249725836