Lifecourse predictors of adult fibrinogen concentrations: the Newcastle Thousand Families Birth Cohort
Year: 2009
Type: conference-abstract
Abstract: characteristics interact so that combinations of factors carry cumulative risk for CVD? (iii) are associations explained by early life predictors of CVD risk.Design: Birth cohort.Setting: England, Scotland and Wales.Participants: 7916 men and women in the 1958 British birth cohort who were in paid employment at 45 y.Main Outcome Measures: Body mass index (BMI), waist circumference (WC), blood pressure (BP), triglycerides, total and high density lipoprotein (HDL) cholesterol, glycosylated haemoglobin (HbA1c), and inflammatory factors: fibrinogen, C-reactive protein (CRP).Results: Night work was associated with adverse levels of most outcomes examined (except BP and total cholesterol).Working >48 h/week was associated with BMI and WC only; low job control with HDL, HbA1c, and inflammatory factors; low demands, rather than high demands, with systolic BP, triglycerides, HDL and inflammatory factors.Several work factor/CVD associations were weakened when mutually adjusted for each other and an interaction between night work and low demands was commonly found.Adjustment for childhood factors up to 16 y explained a substantial proportion of the associations.To illustrate, for BMI, adjustment for a range of childhood factors reduced the associations for night work/low demands (0.78 kg/m 2 , 95% CI 0.35 to 1.21) and working >48 h/week (0.31 kg/m 2 , 20.01 to 0.62) by 50% and 22%, respectively.However, BMI at 16 y accounted for 45% of the association between working >48 h/week and BMI at 45 y (adjustment for some childhood factors strengthened the association between work hours and BMI).Conclusions: Initial findings suggest that childhood factors up to the age of 16 y explain a large proportion of the cross-sectional associations seen for work characteristics and risk factors for CVD in mid-adulthood suggesting that associations arise in part from social and health disadvantage originating earlier in life.
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1996565795