Year: 2003
Type: review
Abstract: With improvements in survival rates for children and adolescents diagnosed with leukaemia or lymphoma, issues relating to late treatment-related sequelae have increased in importance. Reviewed are selected late adverse outcomes, including second malignancies, cardiotoxicity, endocrinological effects, impact on neurocognitive neuropsychological status, late mortality and implications of stem cell transplantation. While there has been considerable research on the late outcomes among survivors of acute lymphoblastic leukaemia and Hodgkin's disease, future research must be directed towards identification of risks associated with more recent treatment regimens, as well as the very lateoccurring outcomes resulting from treatment protocols utilized three or more decades ago. As treatment-and patient-related factors impact the subsequent risk of lateoccurring adverse outcomes, clear delineation of those leukaemia and lymphoma survivors who are at high risk of specific adverse outcomes is essential for the rational design of follow-up guidelines, prevention and intervention strategies.
Source: British Journal of Haematology
Authors: Leslie L. Robison, Smita Bhatia
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1996574248