Work

Mechanisms of Intron Mobility

Year: 1995

Type: article

Abstract: Group I and group II introns, which splice via RNA-catalyzed pathways, can invade DNA sequences by virtue of proteins expressed from open reading frames (ORFs)1 contained within them. These intron products are endonucleases in the case of group I introns and reverse transcriptases (RTs) with associated endonuclease activity in the case of the group II introns. Two kinds of mobility reactions will be considered for each intron type: homing into cognate intronless alleles and transposition to non-allelic sites.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.270.51.30237

Authors: Marlene Belfort, Philip S. Perlman

Institutions: New York State Department of Health, State University of New York, Wadsworth Center, The University of Texas Southwestern Medical Center

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funder: National Institute of General Medical Sciences