Development of A Segment-Based Aldehyde Dehydrogenase Assay to Determine Umbilical Cord Blood Unit (CBU) Potency
Year: 2009
Type: article
Abstract: Background: Banked, unrelated CBU provides access to transplantation for patients lacking matched donors. However, after CB transplantation (UCBT), up to 20% of patients experience primary graft failure, suggesting that rapid assays to assess CB potency are needed. Preliminary clinical studies demonstrated that post-thaw colony forming units (CFU) predict neutrophil and platelet engraftment as well as overall survival but, time (14 days) and variability limit their usefulness as a potency assay.
Authors: K.W. Shoulars, T. Gentry, E.T. Tracy, K. Page, J. Sun, L. Winstead, A.E. Balber, J. Kurtzberg
Institution: Duke Medical Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W1996927531