Work

Common genetic mechanisms in alcohol, drug, and mental disorder comorbidity

Year: 1995

Type: article

Abstract: Comorbid drug and mental disorders were assessed in 63 monozygotic (MZ) and 67 dizygotic (DZ) twin pairs. DSM-III alcohol dependence was heritable in males when probands had a comorbid DSM-III drug or mental disorder but not when probands had only alcohol dependence. For males, significantly higher cross-MZ than cross-DZ correlations were found between alcohol dependence in probands and certain mental and drug disorders in cotwins. In contrast, females showed higher within-twin than cross-MZ correlations and similar cross-MZ and cross-DZ correlations between alcohol dependence and all mental and drug disorders. These results suggest comorbidity between alcohol and certain drug and mental disorders in males in epidemiological surveys may be due in part to genetic influences.

Source: Drug and Alcohol Dependence

DOI: 10.1016/0376-8716(95)01151-n

Authors: Roy W. Pickens, Dace S. Svikis, Matt McGue, Michele C. LaBuda

Institutions: National Institute on Drug Abuse, Johns Hopkins University, Johns Hopkins Medicine, University of Minnesota

Language: English

Topic: Substance Abuse Treatment and Outcomes

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,380