Work

GPR40: A therapeutic target for mediating insulin secretion

Year: 2012

Type: review

Abstract: G-protein-coupled receptor 40 (GPR40), known as free fatty acid receptor 1, is mainly expressed in pancreatic β-cells and activated by medium- and long-chain fatty acids. Increasing evidence indicates that the activation of GPR40 in cells causes insulin secretion, and GPR40 has become an attractive therapeutic target for type 2 diabetes. Recently, certain novel GPR40 agonists have been identified that regulate glucose-stimulated insulin secretion, leading to the development of new drugs for the treatment of type 2 diabetes. In this review, we focus on progress in the physiological role of GPR40 and potential drugs targeting GPR40 over the past decade.

Source: International Journal of Molecular Medicine

DOI: 10.3892/ijmm.2012.1142

Authors: XIAO-TAO FENG, JING LENG, ZHEN XIE, SHUANG-LEI LI, WEI ZHAO, QIAN-LI TANG

Institutions: Guangxi University of Chinese Medicine, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine

Language: English

Topic: Pancreatic function and diabetes

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, Natural Science Foundation of Guangxi Province