Work

Fragile sites induced by 5-azacytidine and 5-azadeoxycytidine in the murine genome

Year: 2008

Type: article

Abstract: The cytosine analogues 5-azacytidine and 5-azadeoxycytidine were used to induce fragile sites on mouse chromosomes. Sites of relative frequent fragility were ascertained and compared with fragile sites induced by the antimetabolites methotrexate, fluorodeoxyuridine and aphidicolin as reported previously. Considerable overlap of fragile sites induced by the very different agents is evident. Fragile sites are common to all chromosomes and most of them are susceptible to different modes of induction.

Source: Hereditas

DOI: 10.1111/j.1601-5223.1990.tb00140.x

Authors: M. DJALALI, S. ADOLPH, P. STEINBACH, H. WINKING, H. HAMEISTER

Institutions: Universität Ulm, University of Lübeck

Language: English

Topic: Carcinogens and Genotoxicity Assessment

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590