Work

In vivo profiles in malaria are consistent with a novel physiological state

Year: 2009

Type: letter

Abstract: Lemieux et al. (1) describe a reanalysis of our in vivo Plasmodium falciparum patient samples (2), supporting many of our conclusions (exclusive presence of rings, lack of distinct asexual phases in the clusters, a relation between Cluster 1 and gametogenesis). However, Lemieux et al. (1) fit the observed in vivo profiles as a mixture of gametocyte and asexual form mRNA (Fig. 2E in ref. 1), concluding that the discrete clusters are consistent with varying proportions of sexually committed but phenotypically indistinguishable parasites, reflected by the parameter α.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0904478106

Authors: Dyann Wirth, Johanna Daily, Elizabeth Winzeler, Jill P. Mesirov, Aviv Regev

Institutions: Harvard University, Scripps Research Institute, Broad Institute, Massachusetts Institute of Technology

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health