Work

Regeneration of the urodele limb: A review

Year: 2003

Type: review

Abstract: Urodele amphibians have been widely used for studies of limb regeneration. In this article, we review studies on blastema cell proliferation and propose a model of blastemal self-organization and patterning. The model is based on local cell interactions that intercalate positional identities within circumferential and proximodistal boundaries that outline the regenerate. The positional identities created by the intercalation process appear to be reflected in the molecular composition of the cell surface. Transcription factors and signaling molecules involved in patterning are discussed within the context of the boundary/intercalation model.

Source: Developmental Dynamics

DOI: 10.1002/dvdy.10236

Authors: Holly L.D. Nye, Jo Ann Cameron, Ellen A.G. Chernoff, David L. Stocum

Institutions: University of Illinois Urbana-Champaign, Indiana University Indianapolis, Indiana University – Purdue University Indianapolis

Language: English

Topic: Planarian Biology and Electrostimulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: National Science Foundation

Award: Partnerships for Innovation: A Center of Excellence in Regenerative Biology